It�s already proved that the key behind development of a combinational dosage form is solely depends on compatibility between both the drugs. Drugs having different molecular moiety may interact with each other and reduce therapeutic efficacy of one another followed by serious adverse effect. The aim of the present study is to investigate the synthetic and herbal drug compatibility by means of Fourier transform infrared spectroscopy (FTIR), X-ray diffraction study (XRD) and Thin layer chromatography (TLC). The spectrophotometric graphs showed that there was no significant changes in position of functional groups of Curcumin, Tretinoin (O-H, C=O str.). Characteristic peaks of curcumin appeared at a diffraction angle of 2O at 7.950, 8.800, 12.280, 17.290 showing that Curcumin was present as a crystalline form. TLC studies showed that the Rf values of the mixture obtained on the 0th and 30th day were approximately similar to the Rf values of the pure Curcumin and Tretinoin. Therefore, it is concluded that both the drugs were compatible with each other.
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